Mitochondrial Dysfunction in Airway Disease
نویسندگان
چکیده
منابع مشابه
Accuracy of Impulse Oscillometry in Airway Dysfunction
Background: The purpose of this study was to calculate and compare the specificity and sensitivity of impulse oscillometry (IOS) as a new technique in the detection of airways dysfunction by means of a simple pulmonary function test in chemical warfare injured cases suffering from respiratory diseases. Methods: The study was performed prospectively in 100 patients, who complained of dyspnea as ...
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Parkinson’s disease (PD) is the most common neurodegenerative movement disorder characterized by numerous motor symptoms, including bradykinesia, hypokinesia, rigidity, resting tremor, and postural instability and non-motor symptoms, such as autonomic dysfunction, sleep abnormalities, depression, and dementia [1-3]. The motor clinical manifestations are the preferential loss of dopaminergic (DA...
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(mtDNA) disease and the frequency of cardiac involvement, at least 1 in 10–15,000 of the general population will be affected.4 In 1991, the first mtDNA point mutation in the MT-TL1 gene associated with an MCM was described.5 Since then, several mutations, mostly in mitochondrial tRNA genes, have been associated with different MCM phenotypes. At the end of the 20th century, mutations in several ...
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It is clear from a striking convergence of human tissue studies, neurotoxin models, and genetic models that mitochondrial dysregulation plays a central pathogenic role in Parkinson’s disease (PD) and related neurodegenerative conditions. Impaired mitochondrial quality could result from both increased damage and decreased ability to repair or clear damaged mitochondria. In particular, common def...
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ژورنال
عنوان ژورنال: Chest
سال: 2017
ISSN: 0012-3692
DOI: 10.1016/j.chest.2017.03.020